Inhibition of insulin and glucagon release from the perfused rat pancreas by cyproheptadine (Periactinol�, Nuran�)
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چکیده
منابع مشابه
Glucose modulation of amino acid-induced glucagon and insulin release in the isolated perfused rat pancreas.
Interactions between glucose and arginine and a mixture of 20 amino acids found in normal rat serum were studied in the isolated perfused rat pancreas of normal rats, with release of immunoreactive glucagon and insulin as parameters. Secretion of both pancreatic hormones was low during the steady state, whether glucose (5 mM) was included in the perfusion medium or not. This glucose concentrati...
متن کاملGlucagon in Perfused Rat Pancreas
The biosynthesis of glucagon was studied by using the recirculated, isolated perfused rat pancreas. [3H]Tryptophan was initially incorporated into acid-ethanol-extractable protein, which on gel filtration was eluted with a molecular weight ofabout 9000 and contained a small amount of glucagon immunoreactivity. With longer incubation [3H]tryptophan incorporation into a second peak was obtained i...
متن کاملCharacterization of the effects of arginine and glucose on glucagon and insulin release from the perfused rat pancreas.
To characterize the mechanisms by which arginine and glucose affect pancreatic alpha and beta cell function, the effects of these agents over their full dose response, both alone and in various combinations, were studied using the perfused rat pancreas. Arginine (0-38 mM), in the absence of glucose, stimulated biphasic glucagon (IRG) secretion (Km approximately 3-4 mM) at concentrations less th...
متن کاملKinetics of insulin release from the perfused rat pancreas caused by glucose, glucosamine, and galactose.
Under appropriate conditions, not only glucose but also glucosamine and galactose can serve as potent stimulants for insulin release from the isolated, perfused rat pancreas. Since galactose and, probably, glucosamine are not metabolized in the islets, and since these three compounds have in all likelihood common sites of action, it is postulated that a glucoreceptor of broad specificity is inv...
متن کاملAdrenergic modulation of insulin and glucagon secretion from the isolated perfused rat pancreas.
In order to observe the effect of the adrenergic system on pancreatic glucagon secretion in the isolated perfused rat pancreas, phenylephrine, an alpha-adrenergic agonist, and isoproterenol, a beta-adrenergic agonist, were added to the perfused solution. 1.2 microM phenylephrine suppressed glucagon secretion at 2.8 mM glucose, and it also decreased insulin secretion at 11.1 mM glucose. 240 nM i...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1976
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00422086